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KMID : 1123920130270060795
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Korean Journal of Oriental Physiology and Pathology
2013 Volume.27 No. 6 p.795 ~ p.801
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Effect of White Ginseng-Ejung-tang and Red Ginseng-Ejung-tang Water Extract on Production of Chemokines and IL-21 in LPS-induced RAW 264.7 Mouse Macrophages
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Park Wan-Su
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Abstract
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The purpose of this study is to investigate effects of White Ginseng-Ejung-tang (EG) and Red Ginseng-Ejung-tang (ER) water extract on production of various cytokines such as interleukin (IL)-21, IL-25, IL-28β, erythropoietin (EPO), Exodus-2, monocyte chemotactic protein (MCP)-5, macrophage inflammatory protein (MIP)-3α, MIP-3β, Fractalkine, and TARC in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Levels of cytokines were measured by High-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. ER significantly decreased levels of IL-21, IL-25, IL-28β, EPO, Exodus-2, MCP-5, MIP-3α, MIP-3β, TARC, and fractalkine for 24 h incubation at the oncentrations of 25 and 100 ㎍/mL in LPS-induced RAW 264.7 (P < 0.05). But EG did not show any significant effect. These results suggest that ER has anti-inflammtory property related with its inhibition on the production of IL-21, IL-25, IL-28β, and chemokines such as EPO, MCP-5, MIP-3α, MIP-3β, Fractalkine, Exodus-2, and TARC in LPS-induced macrophages.
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KEYWORD
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White Ginseng, Red Ginseng, Ejung-tang, Macrophage, Inflammation, Interleukin, Chemokine
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